Figure 10.

Roles of DEX on pathological manifestation in lung samples in WT and RAGE^-/- rats. Rats were infused continuously with DEX (10 μg·kg^-1·h^-1) or NS through the femoral vein cannula 30 min after CLP. Lung samples (n=10) were subjected to histological measurements at 24 h after CLP. Representative pathological manifestation of lung samples collected from WT and RAGE^-/- rats. (A) Sham group in WT rats, (D) Sham group in RAGE^-/- rats, (B) CLP group in WT rats, (E) CLP group in RAGE^-/- rats, (C) CLP+DEX (10) group in WT rats, (F) CLP+DEX (10) group in RAGE^-/- rats (H&E staining, magnification 200×). DEX, dexmedetomidine.