Table 1.
Experimental treatment and grouping
| Treatment | Group | |
|---|---|---|
| Effects of dexmedetomidine (DEX) on CLP-induced ALI in WT rats (n=10 in each group) | ||
| Sham | Sham-operation plus normal saline (NS) | |
| DEX | Sham-operation plus DEX (10 μg·kg-1·h-1) | |
| CLP | CLP plus NS | |
| CLP+DEX (2.5) | CLP plus DEX (2.5 μg·kg-1·h-1) | |
| CLP+DEX (5) | CLP plus DEX (5 μg·kg-1·h-1) | |
| CLP+DEX (10) | CLP plus DEX (10 μg·kg-1·h-1) | |
| Effects of Anti-RAGE Ab on CLP-induced lung inflammatory cytokines production in the BALF from WT rats (n=10 in each group) | ||
| Sham | Sham-operation plus NS | |
| Anti-RAGE Ab | Sham-operation plus Anti-RAGE Ab (10 mg/kg) | |
| DEX | Sham-operation plus DEX (10 μg·kg-1·h-1) | |
| CLP | CLP plus NS | |
| CLP+Anti-RAGE Ab | CLP plus Anti-RAGE Ab (10 mg/kg) | |
| CLP+DEX (10) | CLP plus DEX (10 μg·kg-1·h-1) | |
| CLP+Anti-RAGE Ab+DEX (10) | CLP plus Anti-RAGE Ab (10 mg/kg) plus DEX (10 μg·kg-1·h-1) | |
| Effects of DEX on CLP-induced lung NF-κB activation and phosphorylation of MAPK in WT rats (n=10 in each group) | ||
| Sham | Sham-operation plus NS | |
| CLP | CLP plus NS | |
| CLP+DEX (2.5) | CLP plus DEX (2.5 μg·kg-1·h-1) | |
| CLP+DEX (5) | CLP plus DEX (5 μg·kg-1·h-1) | |
| CLP+DEX (10) | CLP plus DEX (10 μg·kg-1·h-1) | |
| Effects of DEX on CLP-induced ALI in WT and RAGE-/- rats (n=10 in each group) | ||
| WT | Sham | Sham-operation plus NS |
| CLP | CLP plus NS | |
| CLP+DEX (10) | CLP plus DEX (10 μg·kg-1·h-1) | |
| RAGE-/- | Sham | Sham-operation plus NS |
| CLP | CLP plus NS | |
| CLP+DEX (10) | CLP plus DEX (10 μg·kg-1·h-1) | |