Figure 7.

The nude mice BBB can be protected after treatment of 5 µg/kg AMD3100. Nude mice were executed and their brain tissues were removed for electron microscopic examination. A. In the group, the lanthanum nitrate particles were distributed in brain tissue, which was equivalent to the late stage of metastasis, which indicated the serious damage of BBB (TEM × 8000). B. In the AMD3100 intervention group, lanthanum nitrate particles deposited in the vascular cavity, suggesting that the normal BBB structure (TEM × 25000). C. In the AMD3100 group, lanthanum particles were deposited only between the endothelial cell layer and the basement membrane, which corresponds to early metastasis, suggesting a slight disruption of BBB structure (TEM × 25000). D. EB content in brain tissue was significantly lower in the intervention group than in the control group (n = 3, *p < 0.05).