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. 2017 Dec 15;9(12):5308–5319.

Figure 7.

Figure 7

Changes in neurological deficit scores by inhibitors of HIF-1α and eNOS. We treated rats with preconditioning with hypoxia+GYKI PC for four constitutive days and HIF-1α inhibitor PX-478 or eNOS inhibitor L-NIO before MCAO surgery, then re-measured the neurological deficit score. Both HIF-1α inhibitor PX-478 and eNOS inhibitor L-NIO abolished the effects of hypoxia+GYKI PC on neurological deficit score, while treatment of PX-478 or L-NIO alone had no impact on neurological deficit score. PC: preconditioning; GYKI: GYKI-52466. #: p<0.05. N=10 per group.