Figure 4.

Vγ₄ ^-depleted mice show decreased IMQ-induced psoriasis-like skin inflammation. C57BJ/6 mice that were subjected to induced psoriasis-like dermatitis 28 days prior were randomly divided into two groups, the re-challenged anti-Vγ₄ antibody group and the re-challenged control group. A. Phenotypical presentation of mouse back skin on day 0, 3, and 6 of IMQ treatment. B. The PASI score was determined for the back skin (n=8 per group). C. H&E staining of the back skin (n=3 per group). D. The thickness of the epidermis skin on day 0, 3, and 6 of IMQ treatment (n=3 per group). E. The number of Vγ₄ ⁺γδ T cells in the dermis was evaluated by FACS analysis on day 0, 3, and 6. F. The percent of Vγ₄ ⁺γδ T cells on different days (n=3 per group). The values represent the mean ± SEM. *p<0.05.