Figure 2.

Chidamide and cytarabine synergistically inhibited cell proliferation in MDS cellsat 72 h. (A) Combination index (CI) values for chidamide combined with cytarabine in MDS cells were lower than 1. The effects of these combinations were estimated using the CompuSyn software, which was developed based on the CIequation of Chou-Talalay. CI < 1 indicates synergism; CI =1 indicates additive effect in the absence of synergism or antagonism; CI > 1 indicates antagonism. (B) The combination of chidamide and cytarabine inhibited cell proliferation. Cell inhibition rate (%)=(1-OD450 of isogarcinol group/OD450 of control group)×100%.