Figure 4.

The combination of chidamide and cytarabine induced cell apoptosis in MDS cells at 72 h. (A, B) The combination of chidamide and cytarabine induced cell apoptosis. (C) Western blot analysis showed the expression of the cell apoptosis protein cleaved caspase-3 was up-regulated, but Bcl-2 and Bax were down-regulated following treatment with both agents. * indicates a significant difference as compared with 25 nM chidamide. & indicates a significant difference as compared with 50 nM chidamide. # indicates a significant difference as compared with 50 nM cytarabine.