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. 2017 Oct 20;37(1):63–74. doi: 10.15252/embj.201797833

Figure 2. AlkC encircles damaged DNA .

Figure 2

  1. Two orthogonal views of the PfAlkC/1aR‐DNA complex crystal structure. The protein is colored blue, DNA gold, 1′‐aza‐2′,4′‐dideoxyribose (1aR) magenta, and opposite thymine green. NTB, N‐terminal helical bundle; HLR, HEAT‐like repeat.
  2. AlkC sequence conservation (purple, high; cyan, low) superposed onto the protein surface.
  3. Schematic illustration of AlkC‐DNA interactions. Dashed and wavy lines denote polar and non‐polar interactions, respectively. Residues from HLR and Ig‐like domains are blue and gray, respectively. Contacts to the protein backbone are marked with an asterisk, and symmetry‐related contacts are in parentheses.