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. 2017 Oct 20;37(1):63–74. doi: 10.15252/embj.201797833

Figure 3. The Ig‐like domain is important for AlkCβ function.

Figure 3

  1. Stereoimage of the Ig‐like domain (blue) interactions with the major grove of DNA (gold). DNA‐interacting side chains are shown as sticks, and hydrogen bonds are shown as dashed lines. Superscripts in nucleotide labels refer to damaged (D) and undamaged (U) strands.
  2. Topology of AlkCβ Ig‐like domain. Regions contacting the DNA are highlighted in red.
  3. Release of 3mA from methylated genomic DNA after a 5‐min incubation with either HCl, no enzyme (mock), PfAlkC (WT), or PfAlkC∆C (∆C). Values are mean ± SD (n = 3).