Table 2.
Performance of non-culture tests for invasive candidiasis in various populations.
| Type of IC | Risk Category | Pre-Test Probability of IC * | Post-Test Probability of IC | |||||
|---|---|---|---|---|---|---|---|---|
| β-d-Glucan ** | PCR *** | Ideal Assay **** | ||||||
| Pos. | Neg. | Pos. | Neg. | Pos. | Neg. | |||
| Candidemia | Low | 1% | 4% | <1% | 8% | <1% | 48% | <1% |
| Low-to-moderate | 5% | 17% | 1% | 32% | <1% | 83% | <1% | |
| Moderate | 10% | 31% | 3% | 50% | 1% | 91% | 1% | |
| Intra-abdominal candidiasis | Low-to-moderate | 5% | 11% | 3% | 12% | 1% | 83% | <1% |
| Moderate | 10% | 21% | 6% | 23% | 3% | 91% | 1% | |
| High | 30% | 51% | 22% | 53% | 11% | 97% | 4% | |
PCR: Polymerase chain reaction; Pos: Positive; IC: Invasive candidiasis; Neg: Negative * Pre-test probability of invasive candidiasis is approximated from Table 1; ** Sensitivity/specificity for candidemia and intra-abdominal candidiasis were assumed to be 80%/80% and 60%/75%, respectively; *** Sensitivity/specificity for candidemia and intra-abdominal candidiasis were assumed to be 90%/90% and 80%/70%, respectively; **** Sensitivity/specificity for candidemia and intra-abdominal candidiasis were assumed to be 90%/99% and 90%/99%, respectively.