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. 2017 Oct 11;4(4):16. doi: 10.3390/jcdd4040016

Figure 4.

Figure 4

Optical mapping analyses of embryonic heterozygous (HT) and homozygous (KO) atrial-specific Pitx2 mutants. Observe that atrial activation times are significantly slower in homozygous as compared to heterozygous hearts. In addition, right and left atrial pacing, respectively display similarly slower activation times, demonstrating an inherent electrical difference between heterozygous (HT) and homozygous (KO) atrial-specific Pitx2 mutants.