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. 2017 Dec 10;4(4):23. doi: 10.3390/jcdd4040023

Figure 2.

Figure 2

Differential Anterior-posterior bilaterality of Nodal expression in Cerl2 knock-out (KO) embryos. Bilateral expression of Nodal in the lateral plate mesoderm of Cerl2 KO embryos (50% display bilateral expression: left isomerism) at about E8.0–E8.5 (from 2 to 7 somite pairs). This bilateral expression can be equal in the left or right LPM occupying the totality of both LPMs (panels B, E); or it can be bilateral only in a more posterior or anterior area (panels A, C, D, F). This partial bilaterality can be either more preponderant on the R-LPM (panels C and F) or on the L-LPM (panels A, D). Partial bilaterality is set early on as can be seen in panel F (2–3 somite embryo), and will last until the end of Nodal’s expression in the LPM, at about 7 somites (as can be seen in panel C). Embryo axes coordinates are present in panel A, in white letters: A: anterior; P: posterior; R: Right; L: Left. R-LPM (right—Lateral Plate Mesoderm); L-LPM (left—Lateral Plate Mesoderm).