Table 1.
Kis of FEMPT for receptors and transporters.
| Targets | Ki values (nM) | Targets | Ki values (nM) | Targets | Ki values (nM) |
| 5-HT1A | 0.2 | adrenergicα1 | 180 | D1 | >10,000 |
| 5-HT1B | 122.5 | adrenergicαB | 196 | D2 | 80 |
| 5-HT2A | 406 | adrenergicαD | 142 | D3 | 35 |
| 5-HT2B | 12 | adrenergicα2A | 346 | D4 | 24 |
| 5-HT2C | 343 | adrenergicα2B | 403 | D5 | >10,000 |
| 5-HT3 | >10,000 | adrenergicα2C | 400 | DAT | 407.4 |
| 5-HT5A | 2340 | adrenergicβ1 | 1300 | sigma2 PC12 | 10 |
| 5-HT6 | 71 | adrenergicβ2 | 202 | DAT | 407.4 |
| 5-HT7 | 11 | adrenergicβ3 | 564 | DOR | >10,000 |
| A2, A3, A4 | >10,000 | H1 | 11 | EP | >10,000 |
| BZP | >10,000 | H2 | 1364 | GABA | >10,000 |
| Ca2+ | >10,000 | H3, H4 | >10,000 | smoothened | >10,000 |
| AMPA | >10,000 | hERG | >10,000 | Y2 | >10,000 |
| NET | 6980 | KOR | 1423 | SERT | 6144 |
| NK | >10,000 | M | >10,000 | sigma2 | >10,000 |
| sigma1 | 1014 | MDR1 | >10,000 | VMAT1,2 | >10,000 |
| V1, V2 | >10,000 | MOR | >10,000 | NT1 | >10,000 |
| Na+ channel | >10,000 | mGluR | >10,000 | imidazoline | >10,000 |
| CB1, CB2 | >10,000 | NMDA | >10,000 | ||
| 5-HT1AR Emax | 100% | EC50 | 85 nM | ||