Table 1.
Schematic representation of cytokine function based on tissue analyzed.
| Human | Mice | References | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Classification | Cytokines/Chemokines | Blood/Plasma/Serum | CSF | Lungs | Spleen | Brain | |||||
| Protective cytokines | IFNγ | [40,118,121,122,127,128,130,136] | |||||||||
| IL-12 | [40,100,116,124] | ||||||||||
| IL-2 | NA | NA | [119,120,123] | ||||||||
| Protection support cytokines | IL-6 | NA | NA | [100,117,128,129,130] | |||||||
| IL-18 | NA | NA | NA | [134,135] | |||||||
| IL-23 | NA | NA | NA | [133] | |||||||
| IP10 | NA | [127,130,136,137] | |||||||||
| G-CSF | NA | NA | [71,128,130,138,139] | ||||||||
| GM-CSF | NA | NA | NA | [128,131,138] | |||||||
| TNFα | NA | [41,121,128,130,136,138] | |||||||||
| Non-protective cytokines | IL-5 | NA | NA | [47,112,136,140] | |||||||
| IL-13 | NA | NA | [42,47,112,115,141] | ||||||||
| Cytokines/ chemokines with varying roles |
IL-1β | NA | NA | [136,142,143] | |||||||
| IL-4 | [42,112,115,117,124,131,136,138,144,145] | ||||||||||
| IL-8 | NA | NA | NA | [124,128,129,130,146] | |||||||
| IL-10 | NA | [47,100,117,124,127,129,131,142,146] | |||||||||
| IL-17 | NA | [39,45,112,124,131,138] | |||||||||
| MCP-1 | NA | NA | [131,136,147,148] | ||||||||
| MIP-1α | NA | NA | NA | [40,131,136,148] | |||||||
| RANTES | NA | NA | NA | [47,136] | |||||||
Blue (protective), yellow (neutral), red (non-protective), NA: not available.