Table 6.

Anti-HIV activities of SC29EK and its fluorinated derivatives against three HIV strains. The number indicates the position of the dipeptide isostere.

entry	pseudopeptides	EC50 (nM)
		NL4-3	IIIB	Ba-L
1	SC29EK	(2.2 ± 0.2)	(6.5 ± 0.9)	(1.9 ± 0.2)
2	SC29EK-6-Lys-ψ[(Z)-CF=CH]-Lys	(5220 ± 202)	>10 000	(5580 ± 1920)
3	SC29EK-13-Lys-ψ[(Z)-CF=CH]-Lys	(599 ± 96)	(3010 ± 554)	(600 ± 302)
4	SC29EK-20-Lys-ψ[(Z)-CF=CH]-Lys	(663 ± 242)	(2200 ± 712)	(527 ± 95)
5	SC29EK-27-Lys-ψ[(Z)-CF=CH]-Lys	(43 ± 7)	(237 ± 16)	(51 ± 7)