Figure 5.

ProteomicsDB enables the exploration of drug selectivity data from various sources. (A) Starting with the selection of a target protein, the user can filter fitted selectivity curves using several criteria: the EC₅₀ range, the R² and BIC. (B) Violin plots depicting the pEC₅₀ (-log₁₀ EC₅₀) distributions for all compounds targeting the selected protein given the filter criteria from (A). The red marker indicates the EC₅₀ of the selected protein for each drug. Numbers above and below the red marker indicate the number of other target proteins with higher or lower potency, respectively. At the time of writing, Bafetinib shows the most potent and selective inhibition of DDR1 with the given filters. (C) Bar chart displaying the distribution of pEC₅₀ values for Imatinib depicting all of its protein:drug interactions available in ProteomicsDB. (D) The underlying raw data and the fitted model can be investigated on click on one of the bars (black border). The scatter plot highlights the EC₅₀ for the selected protein:drug pair.