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. 2017 Nov 15;46(Database issue):D1091–D1106. doi: 10.1093/nar/gkx1121

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Ligand activity chart for palosuran (ACT-058362, GtoPdb ligand ID 3516), a small molecule urotensin II receptor antagonist. Hovering the mouse over the chart on a datapoint gives the median and range if more than one value is reported for the parameters shown on the horizontal axis. Zero indicates no data are available for that parameter. In the example, the results show the IC50 value for palosuran inhibition of binding was about ∼5000-fold lower in rats compared with humans, showing a major difference between the two species.