Table 1. Guide to PHARMACOLOGY database counts for targets, ligands and interactions from database release 2017.5.
| GtoPdb 2016 | GtoPdb 2018 (±2016) | GtoImmuPdb 2018 | |
|---|---|---|---|
| A. Target class content. Human UniProtKB accession counts | |||
| 7TM receptors* | 395 | 395 (0) | 86 |
| Nuclear hormone receptors | 48 | 48 (0) | 6 |
| Catalytic receptors | 239 | 243 (+4) | 107 |
| Ligand-gated ion channels | 84 | 81 (-3) | 3 |
| Voltage-gated ion channels | 141 | 144 (+3) | 17 |
| Other ion channels | 47 | 49 (+2) | 0 |
| Transporters | 508 | 509 (+1) | 5 |
| Enzymes (all) | 1164 | 1184 (+20) | 134 |
| Kinases | 539 | 546 (+7) | 79 |
| Proteases | 240 | 243 (+3) | 32 |
| Other proteins | 135 | 174 (+39) | 64 |
| Total number of targets | 2761 | 2834 (+73) | 420** |
| B. Ligand category counts | |||
| Synthetic organics | 5055 | 5807 (+752) | 449 |
| Metabolites | 582 | 584 (+2) | 23 |
| Endogenous peptides | 759 | 782 (+23) | 176 |
| Other peptides including synthetic peptides | 1222 | 1297 (+75) | 37 |
| Natural products | 234 | 247 (+13) | 9 |
| Antibodies | 138 | 223 (+85) | 121 |
| Inorganics | 34 | 38 (+4) | 1 |
| Approved drugs | 1233 | 1334 (+101) | 208 |
| Withdrawn drugs | 67 | 67 (0) | 11 |
| Ligands with INNs | 1882 | 2114 (+232) | 336 |
| PubChem CIDs | 6037 | 6702 (+665) | 484 |
| PubChem SIDs | 8024 | 8978 (+954) | 816 |
| Total number of ligands | 8024 | 8978 (+954) | 816 |
| C. Interaction counts | |||
| Human targets with ligand interactions | 1505 | 1684 (+179) | 390 |
| Human targets with quantitative ligand interactions | 1228 | 1431 (+203) | 321 |
| Human targets with approved drug interactions | 554 | 563 (+9) | 152 |
| Primary targets*** with approved drug interactions | 312 | 313 (+1) | 91 |
| Ligands with target interactions | 6796 | 7663 (+867) | 718 |
| Ligands with quantitative interactions (approved drugs) | 5860 | 6716 (+856) | 553 |
| 738 | 824 (+86) | 138 | |
| Ligands with clinical use summaries (approved drugs) | 1724 | 2089 (+365) | 423 |
| 1231 | 1332 (+101) | 208 | |
| Number of binding constants | 44 691 | 46 488 (+1797) | 23 304 |
| Number of binding constants curated from the literature | 13 484 | 15 281 (+1797) | 10 964 |
| References | 27 880 | 31 733 (+3933) | |
* Not all the 7TM receptor records are unequivocally assigned as GPCRs, but for convenience we refer to these generally as GPCRs in the text.
** Thirty-five targets are tagged in GtoImmuPdb but have no Human UniProtKB accession. Thirty-four of these are complexes (only subunits have UniProtKB accessions, and 1 that only has a mouse accession).
*** Primary target indicates the dominant Molecular Mechanism of Action (MMOA)
**** An interaction is only considered part of GtoImmuPdb where both the target and ligand are tagged as relevant to immunopharmacology. The table shows just under one quarter of all the curated interactions in GtoPdb involve targets and ligands of immunological relevance (we are still in the process of identifying these so it is likely to increase).
The table includes a comparison to the figures from the 2016 update (5), and a breakdown for the GtoImmuPdb dataset. Categories are not mutually exclusive and targets and ligands can fall into more than one, therefore totals are not the sum of all other rows.