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. 2017 Nov 2;46(Database issue):D447–D453. doi: 10.1093/nar/gkx1041

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — The procedure for the construction of the iUUCD 2.0 database. First, we searched PubMed to collect experimentally identified UB/UBL regulators. Then, we classified known regulators into distinct families and constructed HMM profiles for each family if available. For families without HMM profiles, we also conducted an orthologous search to ensure data integrity. In addition to basic annotations, we further mapped all regulators in eight model organisms, especially in Homo sapiens, to nearly 70 public databases that covered each of 11 aspects: (i) cancer mutations, (ii) SNPs, (iii) mRNA expressions, (iv) DNA and RNA elements, (v) PPIs, (vi) protein 3D structures, (vii) disease-associated information, (viii) drug-target relations, (ix) PTMs, (x) DNA methylation and (xi) protein expression/proteomics.