Table 6.
Prognostic significance of clinical and histopathologic parameters on ESRD
| Variable | Univariable Analysis | Multivariable Analysisa | Multivariable Analysisb | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | |
| Age, yr | 1.02 (1.01 to 1.03) | <0.01 | 1.01 (1.00 to 1.03) | 0.06 | ||
| Males | 1.19 (0.77 to 1.84) | 0.44 | ||||
| Lung involvement | 1.19 (0.75 to 1.88) | 0.47 | ||||
| Double positivity | 1.07 (0.64 to 1.78) | 0.80 | ||||
| Serum creatinine at presentation ≥5.7 mg/dl | 4.83 (2.75 to 8.47) | <0.001 | 1.98 (0.96 to 4.10) | 0.07 | ||
| Dialysis dependency at presentation | 6.50 (3.68 to 11.47) | <0.001 | a | a | 3.2 (1.6 to 6.3) | 0.001 |
| Histopathologic classification | <0.01 | 0.15 | ||||
| Focal (reference) | ||||||
| Crescentic | 20.29 (2.80 to 147.26) | 8.38 (1.10 to 63.87) | ||||
| Mixed | 11.67 (1.54 to 88.47) | 6.77 (0.87 to 52.65) | ||||
| Sclerotic | 25.72 (3.24 to 204.51) | 11.17 (1.34 to 3.13) | ||||
| Percentage normal glomeruli | 0.95 (0.93 to 0.98) | <0.001 | 0.97 (0.95 to 0.99) | <0.01 | 0.97 (0.95 to 0.99) | 0.01 |
| Percentage cellular crescents | 1.02 (1.01 to 1.02) | <0.001 | 1.02 (1.00 to 1.05) | 0.09 | ||
| Percentage globally Sclerotic glomeruli | 1.01 (1.00 to 1.02) | 0.20 | ||||
| Interstitial fibrosis and tubular atrophy, score 2–3 | 1.88 (1.20 to 2.95) | <0.01 | 1.38 (0.87 to 2.18) | 0.17 | ||
| Interstitial infiltrate, score 2–3 | 2.35 (1.44 to 3.83) | 0.001 | 1.90 (1.16 to 3.13) | 0.01 | 2.02 (1.2 to 3.5) | 0.01 |
| Tubulitis, present | 1.51 (0.96 to 2.35) | 0.07 | ||||
HR, hazard ratio; 95% CI, 95% confidence interval.
a
Each parameter that was significant in univariable analysis, was analyzed in a multivariable analysis including dialysis dependency at presentation. Dialysis dependency at presentation remained significant in each multivariable analysis with P values ≤0.002.
b
Parameters that were significant in the multivariable analysisa were included in this multivariate analysis.