Figure 2.

Visualization of cytochrome P450 2D6 tunnels on entity page. Page shows the 3D structure of cytochrome P450 2D6 (PDB ID: 3TBG) with two channels selected in the Channels tab—solvent (yellow) and 2f (purple). The ligands present within the structure are shown as vdW spheres, including one of the thioridazine molecules resting within channel 2f (magenta). The red rectangle on the interactive Channel profile tab is locked by the mouse on the channel's bottleneck, and its properties are shown in the Layer tab. The lining residues tab then lists all residues along the selected channel. Residue and Protein annotations tabs use data from UniProt to show known residue mutations for this UniProt ID, its function and catalytic activity.