Table 3. Multivariate mixed models showing associations between change in ceramide C18:0 and change in 4 cognitive domain Z-scores over 6 months of cardiac rehabilitation (CR) in patients with coronary artery disease (CAD).
| Cognitive domain (outcome variable) | Ceramide C18:0 | |
|---|---|---|
| b (SE) | p-value (p≤0.05)* | |
| Visuospatial memory2 | -0.44 (0.22) | 0.05* |
| Processing speed3 | -0.89 (0.32) | 0.007* |
| Executive function4 | -0.59 (0.31) | 0.06 |
| Global cognition (MoCA score)5 | -1.47 (0.59) | 0.01* |
2
model also included years of education, stent procedure, statin dose, dihydrosphingomyelin C20:0 and monohexylceramide C26:1
3
model also included years of education, ethnicity, stent procedure, diabetes, VO2peak, sphingomyelin C18:1, ceramide C22:0, ceramide C24:1, monohexylceramide C18:0, monohexylceramide C26:1 and sphingosine
4
model also included years of education, ethnicity, diabetes, VO2peak, serum HDL concentration, sphingomyelin C18:1, ceramide C22:0, ceramide C24:1 and monohexylceramide C18:0
5
model also included years of education, ethnicity, weight, β-adrenergic receptor blocker use, statin dose, lactosylceramide C18:1and lactosylceramide C24:1