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Osteosarcoma metastases display in situ fluorescence during intraoperative molecular imaging. Four hours after delivery of OTL38, osteosarcoma metastases display fluorescence during real-time molecular imaging. This technology may help surgeons localize nodules found by preoperative imaging or identify additional small disease deposits which are undetectable using standard imaging/intraoperative modalities. (Video 1, 18.1 MB, mp4 [URL: http://dx.doi.org/10.1117/1.JBO.23.1.016005.1]).
