Table 4.
Genotyping results of the voltage-gated sodium channel gene at 1534 codon and association with resistance to DDT in five Aedes albopictus populations in Guangzhou, China. The significance threshold is P < 0.01 after Bonferroni correction for multiple testing
| Area | Population | Phenotype | n | Genotype | Odds ratio (95% CI) | P–value of Fisher’s exact probability test | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FF | FS | SS | FL | LL | LS | F1534S | F1534 L | F1534S | F1534 L | ||||
| Urban | UBT | R | 28 | 2 | 11 | 12 | 1 | 0 | 2 | 1.9 (0.94–3.96) | 1.9 (0.38–9.34) | 0.052 | 0.353 |
| S | 46 | 15 | 9 | 18 | 1 | 0 | 3 | ||||||
| UYS | R | 39 | 5 | 9 | 7 | 6 | 1 | 11 | 2.3 (1.19–4.59) | 2.2 (1.00–4.86) | 0.010 | 0.040 | |
| S | 52 | 13 | 19 | 3 | 10 | 1 | 7 | ||||||
| Suburban | SBL | R | 10 | 3 | 6 | 1 | 0 | 0 | 0 | 0.9 (0.31–2.51) | na | 0.519 | 0.542 |
| S | 29 | 11 | 9 | 7 | 1 | 0 | 1 | ||||||
| SPX | R | 10 | 0 | 1 | 8 | 0 | 0 | 1 | 4.2 (0.50–34.24) | 2.0 (0.11–37.83) | 0.143 | 0.589 | |
| S | 35 | 5 | 2 | 22 | 0 | 0 | 6 | ||||||
| Rural | RCD | R | 13 | 8 | 3 | 2 | 0 | 0 | 0 | 1.0 (0.37–2.72) | na | 0.587 | 0.346 |
| S | 43 | 22 | 16 | 1 | 0 | 0 | 4 | ||||||
Abbreviations: F wildtype F1534 allele, S F1534S allele, L F1534 L, R resistant, S susceptible, na not applicable, FF homozygous phenylalanine/phenylalanine, FS heterozygotes phenylalanine/ leucine, SS homozygous serine/serine, FL heterozygotes phenylalanine/ leucine, LL homozygous leucine/ leucine, SL heterozygotes serine/leucine