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. 2018 Jan 4;18:1. doi: 10.1186/s12874-017-0458-6

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Comparison of first positive screen time between methods in the validation cohort within 2 years of clinical diagnosis (C1 in Fig. 2). AFP+Lab+ ΔAFP: updated laboratory-based algorithm, PEB: parametric empirical Bayes algorithm applied to AFP