Table 2.
Results from validation cohort | ||||||||
---|---|---|---|---|---|---|---|---|
Screening algorithm | A1 | B1 | C1 | D1 | A2 | B2 | C2 | D2 |
AFP only | 0.5753 | 0.5672 | 0.5442 | 0.5388 | 0.4019 | 0.4099 | 0.3564 | 0.3361 |
AFP+Lab+ ΔAFP | 0.6137 | 0.6119 | 0.5907 | 0.5809 | 0.4766 | 0.4820 | 0.4158 | 0.3770 |
PEB: AFP | 0.6055 | 0.6045 | 0.6023 | 0.6364 | 0.4579 | 0.4955 | 0.4653 | 0.4891 |
Number of HCC cases | 365 | 402 | 430 | 451 | 107 | 222 | 303 | 366 |
A1: τ1=6 months and τ2=0, B1: τ1=12 months and τ2=0, C1: τ1=24 months and τ2=0, D1: τ1 is the maximum follow-up time and τ2=0. A2: τ1=6 months and τ2=3 months, B2: τ1=12 months and τ2=3 months, C2: τ1=24 months and τ2=3 months, D2: τ1 is the maximum follow-up time and τ2=3 months. AFP+Lab+ ΔAFP: updated laboratory-based algorithm, PEB: AFP: parametric empirical Bayes algorithm applied to AFP