Table 2.
Distribution of molecular alterations between right-sided and left-sided metastatic colorectal cancer
| All (n = 161) | Right-sided mCRC (n = 38) | Left-sided mCRC (n = 123) | p-value | ||
|---|---|---|---|---|---|
| Extended RAS status | Wild-typea | 89 (58) | 19 (50) | 70 (60) | 0.352b |
| Mutanta | 65 (42) | 19 (50) | 46 (40) | ||
| Not available | 7 | 0 | 7 | ||
| KRAS Exon 2 | Wild-typea | 97 (62) | 20 (53) | 77 (65) | 0.229b |
| Mutanta | 59 (38) | 18 (47) | 41 (35) | ||
| Not available | 5 | 0 | 5 | ||
| KRAS Exon 3 | Wild-typea | 145 (99) | 38 (100) | 107 (99) | 1.000b |
| Mutanta | 1 (1) | 0 (0) | 1 (1) | ||
| Not available | 15 | 0 | 15 | ||
| KRAS Exon 4 | Wild-typea | 144 (98) | 37 (97) | 107 (98) | 1.000b |
| Mutanta | 3 (2) | 1 (3) | 2 (2) | ||
| Not available | 14 | 0 | 14 | ||
| NRAS Exon 2 | Wild-typea | 144 (99) | 38 (100) | 106 (98) | 1.000b |
| Mutanta | 2 (1) | 0 (0) | 2 (2) | ||
| Not available | 15 | 0 | 15 | ||
| NRAS Exon 3 | Wild-typea | 145 (99) | 38 (100) | 107 (99) | 1.000b |
| Mutanta | 1 (1) | 0 (0) | 1 (1) | ||
| Not available | 15 | 0 | 15 | ||
| NRAS Exon 4 | Wild-typea | 146 (100) | 38 (100) | 108 (100) | 1.000b |
| Mutanta | 0 (0) | 0 (0) | 0 (0) | ||
| Not available | 15 | 0 | 15 | ||
| TP53 mutation | Wild-typea | 84 (60) | 29 (78) | 55 (53) | 0.012b |
| Mutanta | 57 (40) | 8 (22) | 49 (47) | ||
| Not available | 20 | 1 | 19 | ||
| TP53 Exon 5 | Wild-typea | 113 (80) | 32 (86) | 81 (78) | 0.375b |
| Mutanta | 28 (20) | 5 (14) | 23 (22) | ||
| Not available | 20 | 1 | 19 | ||
| TP53 Exon 6 | Wild-typea | 135 (96) | 36 (97) | 99 (95) | 1.000b |
| Mutanta | 6 (4) | 1 (3) | 5 (5) | ||
| Not available | 20 | 1 | 19 | ||
| TP53 Exon 7 | Wild-typea | 131 (93) | 35 (95) | 96 (92) | 0.728b |
| Mutanta | 10 (7) | 2 (5) | 8 (8) | ||
| Not available | 20 | 1 | 19 | ||
| TP53 Exon 8 | Wild-typea | 126 (89) | 37 (100) | 89 (86) | 0.012b |
| Mutanta | 15 (11) | 0 (0) | 15 (14) | ||
| Not available | 20 | 1 | 19 | ||
| TP53 Exon 9 | Wild-typea | 86 (100) | 25 (100) | 61 (100) | NA |
| Mutanta | 0 (0) | 0 (0) | 0 (0) | ||
| Not available | 75 | 13 | 62 | ||
| BRAF Exon 15 | Wild-typea | 136 (99) | 34 (100) | 102 (99) | 1.000b |
| Mutanta | 1 (1) | 0 (0) | 1 (1) | ||
| Not available | 24 | 4 | 20 | ||
| PI3K | Wild-typea | 129 (96) | 34 (97) | 95 (95) | 0.677b |
| Mutanta | 6 (4) | 1 (3) | 5 (5) | ||
| Not available | 26 | 3 | 23 | ||
| PI3K Exon 9 | Wild-typea | 132 (99) | 34 (100) | 98 (98) | 1.000b |
| Mutanta | 2 (1) | 0 (0) | 2 (2) | ||
| Not available | 27 | 4 | 23 | ||
| PI3K Exon 20 | Wild-typea | 137 (97) | 36 (97) | 101 (97) | 1.000b |
| Mutanta | 4 (3) | 1 (3) | 3 (3) | ||
| Not available | 20 | 1 | 19 |
Percentage in brackets, aincluded categories, btwo-sided Fisher’s exact test, Χ2-test with Yates’ correction in all other cases