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. 2018 Jan 4;15:3. doi: 10.1186/s12974-017-1037-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Effects of the IDO inhibitor 1-MT (1, 3, and 9 mg/kg) on memory deficits (a, b) and locomotor activity (c) induced by BDL in rats. Chronic treatment with 1-MT improves learning and memory behaviors in the Morris water maze task during the 1-h (a1, a2) or 24-h (b1, b2) test trials. Locomotor activity was assessed by the total number of counts recorded for 10 min in BDL animals in different days (0, 7, 14, 21, and 28 days) after surgery. Data are expressed as mean ± SEM (n = 8). **p < 0.01 and ***p < 0.001, when compared to the sham group; ^##p < 0.01, when compared to the BDL group