Table 4.

Symptom-based therapy adjustment (all therapeutic adjustments will be automatically calculated and advised by the e-CRF)

Asthma Control (ACQ7)	Treatment increased according to Table 5
ACQ7 ≥ 1.5 and ≥ 1 change from baseline score OR severe exacerbation since last visit (past 8 weeks at baseline randomisation visit)	Increase therapy 1 step
ACQ7 is 1.0 to < 1.5 OR ACQ ≥ 1.5 and < 1 change from baseline score AND no severe exacerbation since last study visit (past 8 weeks at baseline randomisation visit)	No change
ACQ7 < 1.0 AND no severe exacerbation since last study visit (prior 8 weeks at baseline randomisation visit)	Reduce therapy 1 step

All therapeutic adjustments will be automatically calculated and advised by the electronic case report form (e-CRF)

ACQ7 7-item Asthma Control Questionnaire