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Operating characteristics for detecting differences in the primary endpoint
| Total N (intervention + control) |
Ratio | Type 1 error | Proportion of patients achieving a reduction in ICS or OCS | Power | ||
|---|---|---|---|---|---|---|
| Control | Intervention | Difference | ||||
| 400 (320 + 80) | 4:1 | 0.05 | 10% | 26% | 16% | 83% |
| 300 (240 + 60) | 4:1 | 0.05 | 10% | 29% | 19% | 83% |
| 200 (160 + 40) | 4:1 | 0.05 | 10% | 34% | 24% | 83% |
Assumes a 20% drop out rate
ICS inhaled corticosteroid, OCS oral corticosteroid
