Table 1. Immune-stimuli that induce the non-canonical NF-κB pathway.
| Ligands | Receptors | Refs |
|---|---|---|
| TNF superfamily members | ||
| BAFF | BAFFR | 30,32 |
| CD40L | CD40 | 31 |
| CD30L | CD30 | 35,36 |
| CD70 | CD27 | 34 |
| LTα1β2 and LIGHT | LTβR | 29 |
| OX40L | OX40 | 38 |
| RANKL | RANK | 37 |
| TNF (membrane) | TNFR2 | 39 |
| TWEAK | FN14 | 33 |
| Other immune stimuli | ||
| MCSF | MCSFR | 40 |
| MACs | NA | 75 |
| Antibodies directed against CD3 and CD28 | TCR and CD28 | 25 |
BAFF, B cell activating factor; FN14, fibroblast growth factor-inducible factor 14; L, ligand; LIGHT, also known as TNFSF14; LT, lymphotoxin; MACs, membrane attack complexes; MCSF, macrophage colony-stimulating factor; NA, not applicable; R, receptor; RANK, receptor activator for NF-κB; TCR, T cell receptor; TNF, tumour necrosis factor; TWEAK, TNF-like weak inducer of apoptosis.