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. Author manuscript; available in PMC: 2018 Jan 4.
Published in final edited form as: Sci Transl Med. 2012 Feb 22;4(122):122ra22. doi: 10.1126/scitranslmed.3003441

Fig. 5.

Fig. 5

Nicotine triggers inflammation. (A) Mac-1–positive cells (red) are increased in mice supplemented with nicotine compared to placebo in the elastase-induced mouse model of AAAs. Scale bar, 50 µm. (B) Mac-1–positive cells from n = 4 high-power fields (HPF) from 3 different mice per group (12 total per group). (C) Gene expression of Cxcl1, Cxcl12, Il6, and Mcp1 in mice infused with elastase and supplemented with either nicotine or placebo compared with saline-infused control mice (sham). (D) Gene expression of Cxcl1, Cxcl12, Il6, and Mcp1 in mice transduced with anti-21 or pre-21, scr-miR, or empty vector control (pre-con) compared to sham 14 days after induction of AAA by elastase infusion. n = 3 to 7 per treatment group. Data are means ± SEM. *P < 0.05 versus sham; #P < 0.05 versus scr-miR, empty vector control (pre-con), and sham (or versus elastase + placebo and versus sham). Level of significance was determined using one-way ANOVA with Bonferroni’s post test, or Student’s t test for parametric measures (B).