Table 2. . Genotype and allele frequencies of NUDT15 and TPMT variants.
| Gene | Variants | n | Genotype frequency (n [%]) | Allele frequency | |||
|---|---|---|---|---|---|---|---|
| CC | CT | TT | C | T | |||
| NUDT15 | c.415G>T (rs116855232) | ||||||
| All patients | 129 | 111 (86.0) | 16 (12.4) | 2 (1.6) | 0.89 | 0.11 | |
| Chinese | 84 | 70 (83.3) | 12 (14.3) | 2 (2.4) | 0.86 | 0.14 | |
| Malays | 12 | 11 (91.7) | 1 (8.3) | 0 (0) | 0.88 | 0.12 | |
| Indians | 31 | 29 (93.5) | 2 (6.5) | 0 (0) | 0.92 | 0.08 | |
| c.416G>A (rs147390019) | GG | GA | AA | G | A | ||
| All patients | 129 | 129 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| Chinese | 84 | 84 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| Malays | 12 | 12 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| Indians | 31 | 31 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| c.52G>A (rs186364861) | GG | GA | AA | G | A | ||
| All patients | 129 | 127 (98.4) | 2 (1.6) | 0 (0) | 0.99 | 0.01 | |
| Chinese | 84 | 83 (98.8) | 1 (1.2) | 0 (0) | 0.99 | 0.01 | |
| Malays | 12 | 11 (91.7) | 1 (8.3) | 0 (0) | 0.96 | 0.04 | |
| Indians | 31 | 31 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| c.36_37insGGAGTC (rs554405994) | WT | HET | HV | WT | V | ||
| All patients | 129 | 118 (91.5) | 11 (8.5) | 0 (0) | 0.96 | 0.04 | |
| Chinese | 84 | 73 (86.9) | 11 (13.1) | 0 (0) | 0.93 | 0.07 | |
| Malays | 12 | 12 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| Indians | 31 | 31 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| TPMT | *2 (rs1800462) | GG | GC | CC | G | C | |
| All patients | 129 | 129 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| Chinese | 84 | 84 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| Malays | 12 | 12 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| Indians | 31 | 31 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| *3A (rs1800460 and rs1142345) | WT | HET | HV | WT | V | ||
| All patients | 129 | 129 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| Chinese | 84 | 84 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| Malays | 12 | 12 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| Indians | 31 | 31 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| *3B (rs1800460) | GG | GA | AA | G | A | ||
| All patients | 129 | 129 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| Chinese | 84 | 84 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| Malays | 12 | 12 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| Indians | 31 | 31 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| *3C (rs1142345) | AA | AG | GG | A | G | ||
| All patients | 129 | 127 (98.4) | 2 (1.6) | 0 (0) | 0.98 | 0.02 | |
| Chinese | 84 | 82 (97.6) | 2 (2.4) | 0 (0) | 0.97 | 0.03 | |
| Malays | 12 | 12 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| Indians | 31 | 31 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| *6 (rs75543815) | AA | AT | TT | A | T | ||
| All patients | 129 | 128 (99.2) | 1 (0.8) | 0 (0) | 0.99 | 0.01 | |
| Chinese | 84 | 83 (98.8) | 1 (1.2) | 0 (0) | 0.98 | 0.02 | |
| Malays | 12 | 12 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
| Indians | 31 | 31 (100) | 0 (0) | 0 (0) | 1.00 | 0.00 | |
HET: Heterozygous; HV: Homovariant; V: Variant; WT: Wild-type.