Table 3. . Associations of NUDT15 variants with thiopurine-induced leukopenia and neutropenia.
| Genotype groups | Log-additive model | Dominant model | |||||
|---|---|---|---|---|---|---|---|
| Variants | Myelotoxicity | CC (n = 111) | CT (n = 16) | TT (n = 2) | p-value | OR (95% CI) | p-value |
| NUDT15 c.415C>T (rs116855232) | |||||||
| Leukopenia (WBC <3.0 × 109/l) | 3 (2.7%) | 5 (31.3%) | 2 (100%) | 0.002* | 22.9 (5.17–101.4) | 3.71 × 10-5* | |
| Grade 2 | 2 | 2 | 0 | ||||
| Grade 3 | 1 | 3 | 0 | ||||
| Grade 4 | 0 | 0 | 2 | ||||
| Neutropenia (ANC <1.5 × 109/l) | 4 (3.6%) | 4 (25.0%) | 2 (100%) | 0.018* | 13.4 (3.30–54.2) | 2.79 × 10–12.79 × 10-4* | |
| Grade 2 | 2 | 3 | 0 | ||||
| Grade 3 | 2 | 0 | 0 | ||||
| Grade 4 | 0 | 1 | 2 | ||||
| NUDT15 c.36_37insGGAGTC (rs554405994) | WT/WT (n = 118) | WT/Ins (n = 11) | Ins/Ins (n = 0) | ||||
| Leukopenia (WBC <3.0 × 109/l) | 7 (5.9%) | 3 (27.3%) | – | – | 5.95 (1.29–27.5) | 0.022* | |
| Grade 2 | 3 (2.5%) | 1 (9.1%) | |||||
| Grade 3 | 4 (3.4%) | 2 (18.2%) | |||||
| Grade 4 | 0 (0%) | 0 (0%) | |||||
| Neutropenia (ANC <1.5 × 109/l) | 8 (6.8%) | 2 (18.2%) | – | – | 3.06 (0.56–16.6) | 0.196 | |
| Grade 2 | 4 (3.4%) | 1 (9.1%) | |||||
| Grade 3 | 2 (1.7%) | 0 (0%) | |||||
| Grade 4 | 2 (1.7%) | 1 (9.1%) | |||||
*p < 0.05.
ANC: Absolute neutrophil count; OR: Odds ratio; WBC: White blood cell; WT: Wild-type.