Table 1. . Frequencies of heterogenous alleles of HLA-B loci.
HLA-B allele | Frequency (%) | Case with SJS/TEN vs general control | Case with SJS/TEN vs tolerant control | ||||
---|---|---|---|---|---|---|---|
SJS/TEN (n = 12) | General control (n = 236)† | Tolerant control (n = 17) | Odds ratio (95% CI) | p-value | Odds ratio (95% CI) | p-value | |
07:02 | – | 4 (1.7%) | – | – | – | – | – |
07:05 | – | 12 (5.1%) | 2 (11.8%) | – | – | – | – |
13:01 | – | 6 (2.5%) | – | – | – | – | – |
13:02 | – | 5 (2.1%) | – | – | – | – | – |
15:02 | 8 (66.7%) | 54 (22.9%) | 4 (29.4%) | 6.78 (1.96–23.38) | 0.0021 | 6.5 (1.2–33.57) | 0.029 |
15:12 | – | 6 (2.5%) | – | – | – | – | – |
15:13 | – | 51 (21.6%) | 2 (11.8%) | – | – | – | – |
15:17 | – | 4 (1.7%) | – | – | – | – | – |
15:21 | 2 (16.7%) | 33 (14%) | 1 (5.9%) | 1.24 (0.26–5.89) | 1 | 3.2 (0.26–40.05) | 0.55 |
15:214 | 1 (8.3%) | – | 1 (5.9%) | – | – | – | – |
15:25 | – | 8 (3.4%) | – | – | – | – | – |
15:32 | – | 4 (1.7%) | – | – | – | – | – |
18:01 | 4 (33.3%) | 29 (12.3%) | 1 (5.9%) | 3.59 (1.02–12.66) | 0.06 | 8 (0.76–83.88) | 0.12 |
18:02 | – | 8 (3.4%) | 2 (11.8%) | – | – | – | – |
18:33 | – | – | 1 (5.9%) | – | – | – | – |
27:06 | – | 14 (5.9%) | – | – | – | – | – |
35:01 | – | – | 2 (11.8%) | – | – | – | – |
35:02 | – | – | 1 (5.9%) | – | – | – | – |
35:03 | – | 11 (4.7%) | – | – | – | – | – |
35:05 | 1 (8.3%) | 39 (16.5%) | 4 (23.5%) | 0.42 (0.053–3.36) | 0.49 | 0.29 (0.02–3.04) | 0.37 |
35:32 | 1 (8.3%) | – | – | – | – | – | – |
38:02 | – | 25 (10.6%) | – | – | – | – | – |
40:01 | – | 17 (7.2%) | 1 (5.9%) | – | – | – | – |
40:06 | – | 4 (1.7%) | – | – | – | – | – |
44:03 | 3 (25%) | 42 (17.8%) | 5 (29.4%) | 0.46 (0.58–3.68) | 0.7 | 0.8 (0.15–4.26) | 1 |
44:13 | 1 (8.3%) | – | – | – | – | – | – |
51:01 | – | 15 (6.4%) | 2 (11.8%) | – | – | – | – |
51:02 | – | 16 (6.8%) | – | – | – | – | – |
52:01 | – | 5 (2.1%) | – | – | – | – | – |
52:02 | – | – | 2 (11.8%) | – | – | – | – |
56:02 | – | 4 (1.7%) | – | – | – | – | – |
57:01 | – | 6 (2.5%) | – | – | – | – | – |
58:01 | – | 27 (11.4%) | – | – | – | – | – |
B others | – | 15 (6.4%) | – | – | – | – | – |
†From Javanese and Sundanese General Population [25].
‘–’ no data available.
SJS/TEN: Stevens–Johnson syndrome/toxic epidermal necrolysis.