Effect of Compound C on liver cytokine expression in berberine-treated mice. Mice injected with concanavalin A (Con A)- were pretreated with 100 mg/kg berberine with or without 20 mg/kg Compound C for three days. At 8 hours after Con A injection, the TNF-α (A), IFN-γ (B), IL-1β (C), IL-2 (D), and IL-10 (E) mRNA levels in liver tissue were detected by quantitative polymerase chain reaction (qPCR) (n = 6). ** P<0.01 vs. the control group, ##
P<0.01 vs. the Con A group, §§
P<0.01 vs. the Con A plus berberine group.