Table 2.
Cytotoxic activities of isosteviol derivatives against human leukemia suspension cancer cell lines a.
| Compound | IC50 (µM) | Compound | IC50 (µM) | ||
|---|---|---|---|---|---|
| MOLT-4 (Leukemia) | HL-60 (Leukemia) | MOLT-4 (Leukemia) | HL-60 (Leukemia) | ||
| 12a | 5.02 ± 0.15 | 28.8 ± 0.63 | 13a | 12.8 ± 0.54 | 42.38 ± 2.89 |
| 12b | 7.27 ± 0.32 | 35.68 ± 1.08 | 13b | 21.04 ± 1.03 | 63.62 ± 3.02 |
| 12c | 35.49 ± 0.77 | 46.77 ± 1.47 | 13c | 31.26 ± 1.28 | 32.89 ± 1.87 |
| 12d | >100 | >100 | 13d | >100 | >100 |
a Cell viability was analyzed by the CellTiter-Glo® Luminescent Cell Viability Assay. All measurements were performed in triplicate. Data was represented as mean ± standard deviation (SD).