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. 2018 Jan 1;49(1):184–192. doi: 10.1161/STROKEAHA.117.018904

Figure 2.

Figure 2.

MCC950 inhibits NOD-like receptor (NLR) family, NLRP3 (pyrin domain-containing protein 3) inflammasome activation and IL (interleukin)-1β expression. Intracerebral hemorrhage (ICH) was induced in C57BL/6 mice by injection of autologous blood. Mice received daily intraperitoneal (IP) injections of MCC950 (10 mg/kg) or an equal volume of vehicle for 3 consecutive days starting immediately after ICH induction. At day 3 after ICH or sham surgery, brain tissues were harvested for the extraction of mRNA and protein. A, The mRNA expression levels of the NLRP3 inflammasome components and IL-1β after ICH. B, Western blot images show the expression of NLRP3, IL-1β, and caspase-1 in the brains of indicated groups of mice receiving sham plus vehicle, ICH plus vehicle, or ICH plus MCC950. C, Data points show the protein expression levels of NLRP3, IL-1β, and caspase-1 in the brains of indicated groups of mice receiving sham plus vehicle, ICH plus vehicle, or ICH plus MCC950. n=6 mice per group. Data are presented as mean±SD. *P<0.05, **P<0.01.