Skip to main content
. 2017 Dec 2;47(1):18–24. doi: 10.1097/MPA.0000000000000953

FIGURE 2.

FIGURE 2

Effect of TRO40303 on necrotic cell death pathway activation induced by FAEE in PACs. A, Palmitoleic acid ethyl ester (100 μM) exposure increased PI uptake, whereas pretreatment with TRO40303 (10 μM) reduced necrotic cell death pathway activation in response to POAEE (POAEE vs POAEE plus TRO40303, *P < 0.05). B, Simultaneous comparison of PI uptake in response to POAEE (50 μM) alone or with 1, 3, or 10 μM TRO40303 pretreatment. Aggregate curves and paired analysis showed that all concentrations protected PACs against POAEE-induced cell death, in a concentration-dependent manner; n indicates number of independent experiments.