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. 2015 Sep 30;26(6):2681–2699. doi: 10.1177/0962280215606155

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© The Author(s) 2015

This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — (a) Estimated type I error rate and 95% CI under various scenarios. (b) Estimated type I error rate and 95% CI under various design options. Adaptation rule #1: adapts percentage randomised to each dose in proportion to the current estimate of the probability that it is efficacious in MBL reduction. Adaptation rule #2: alters randomisation according to the precision of the estimated response at the ED95 (the minimum dose with near-maximal efficacy). (c) Estimated type I error rate and 95% CI, overall and under various design options.

Figure 5. — (a) Estimated type I error rate and 95% CI under various scenarios. (b) Estimated type I error rate and 95% CI under various design options. Adaptation rule #1: adapts percentage randomised to each dose in proportion to the current estimate of the probability that it is efficacious in MBL reduction. Adaptation rule #2: alters randomisation according to the precision of the estimated response at the ED95 (the minimum dose with near-maximal efficacy). (c) Estimated type I error rate and 95% CI, overall and under various design options.