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Identification of heterozygous deletions in two unrelated probands with nonsyndromic cleft lip and palate. The deletion detected in proband 1 removes the entirety of ISM1 and SPTLC3, while the deletion in proband 2 occurs just 3′ of ISM1. Plots of aCGH data were generated by Nexus 7 software. aCGH, comparative genomic hybridization; CLP, cleft lip and palate.
