Figure 1.

Diet ingredient profiles and geographic origins. (a) The purified control mouse diet, used for comparison to the American diet in our study, is typical of those used in mouse research. (b) Previous studies have evaluated metabolic effects using Western or high-fat diets. Instead, we designed human-comparable diets representative of the dietary patterns in human populations including: (c) a contemporary American diet, (d) a traditional Mediterranean diet, (e) a ketogenic diet analogous to the Maasai diet, and (f) a traditional Japanese diet.