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. 2017 Nov 20;208(1):399–417. doi: 10.1534/genetics.117.300536

Figure 4.

Figure 4

Comparison of metabolic phenotypes in each strain for mice fed Mediterranean, Japanese, or ketogenic diets relative to the American diet. Effects of Mediterranean, Japanese, and ketogenic diets relative to the American diet in each strain are shown for (a) activity (n = 8–10), (b) heat expenditure (n = 8–10), (c) food intake (n = 4–10), (d) water intake (n = 7–10), (e) body weight (n = 17–20), and (f) percent body fat (n = 17–20). The influence of activity and metabolic rate on percent body fat varies by strain and diet, as shown for mice in which metabolic rate and activity was measured (g). Effects of Mediterranean, Japanese, and ketogenic diets relative to the American diet in each strain are shown for (h) HDL cholesterol (n = 4–10), (i) LDL cholesterol (n = 4–10), (j) glucose tolerance test (n = 9–20), and (k) liver triglyceride concentration (n = 11–20). Data are mean ± SE. * P < 0.05, ** P < 0.01, and *** P < 0.001 by ANOVA between means, with Dunnett’s correction to the American diet within each strain. A, A/J strain mice; B6, C57BL/6J strain mice; FVB, FVB/NJ strain mice; HDL high-density lipoprotein; LDL, low-density lipoprotein; NOD, NOD/ShiLtJ strain mice.