Table 2.
The Comparison of Metrics Between Patients With and Without Response to Proton Pump Inhibitor Treatment
| PPI effective (n = 60) | PPI failure (n = 13) | P-value | |
|---|---|---|---|
| Age (yr) | 49.47 ± 13.47 | 45.31 ± 11.98 | 0.308 |
| BMI (kg/m2) | 24.30 ± 2.98 | 23.27 ± 2.49 | 0.249 |
| Male (n [%]) | 35.00 (58.33) | 6.00 (46.15) | 0.422 |
| Erosive esophagitis (n [%]) | 26.00 (43.33) | 3.00 (23.08) | 0.176 |
| Hypersensitive esophagus (n [%]) | 17.00 (28.33) | 8.00 (61.54) | 0.049 |
| Hiatal hernia (n [%]) | 9.00 (15.00) | 0.00 (0.00) | 0.305 |
| DIS (μm) | 0.91 ± 0.18 | 0.82 ± 0.17 | 0.114 |
| Baseline impedance (Ω) | 1621.26 ± 561.17 | 2117.48 ± 428.68 | 0.004 |
| AET% | 14.95 (4.53, 28.83) | 8.00 (1.70, 13.45) | 0.008 |
| Total reflux episodes | 64.50 (51.00, 78.75) | 62.00 (33.00, 93.00) | 0.779 |
| Liquid reflux episodes | 52.27 ± 21.53 | 57.15 ± 39.66 | 0.673 |
| Acid reflux episodes | 30.98 ± 16.43 | 24.38 ± 18.38 | 0.203 |
| Non-acid reflux episodes | 19.00 (10.25, 30.25) | 21.00 (13.50, 45.50) | 0.177 |
| Gas reflux episodes | 10.00 (7.00, 14.00) | 9.00 (6.50, 17.50) | 0.897 |
| Proximal reflux episodes | 26.00 (20.00, 38.00) | 21.00 (12.00, 32.50) | 0.133 |
| Symptom associated with acid (n) | 27 | 7 | 0.562 |
| Symptom associated with non-acid reflux (n) | 13 | 6 | 0.140 |
PPI, proton pump inhibitor; BMI, body mass index; DIS, dilated intercellular spaces; AET, acid exposure time.
The age, BMI, DIS, impedance, liquid reflux, and acid reflux episodes were expressed as mean ± SD, and the AET%, total reflux, non-acid reflux, gas reflux, and proximal reflux episodes were expressed as median (interquartile range).