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. 2017 Dec 18;26(10):1703–1715. doi: 10.1177/0963689717735112

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 8. — Islet survival, expressed as percentage of initial number of islets, after treatment with 0 to 20 μM nanoparticle bilirubin (nBR), free bilirubin (fBR), or empty nanoparticle (eNP) and exposure to 24 h hypoxia. At 12 h after a 24-h period of hypoxia, the number of remaining intact islets in each group was divided by the initial islet count (60 islets per well) to determine the percentage of islets persisting in culture. Islets treated with 5 μM nBR (95.0% intact) and 10 μM fBR (76.7% intact) had a higher percentage of intact islets when compared to control (30% intact).