Table 3.
Relative risks of fractures among apheresis donors in relation to number of apheresis donations in the most recent 2, 5 and 10 years.
| Number of apheresis donations | ||||||||
|
|
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| 2-year exposure window | 1–3 | 4–7 | 8–15 | ≥16 | ||||
| All fractures | Events; incidence rate ratios (95% confidence interval) | |||||||
| Both sexes | 1 637 | 1.00 (0.92–1.08) | 1 038 | 1.00 (ref) | 991 | 0.95 (0.87–1.04) | 924 | 0.94 (0.85–1.03) |
| Women | 611 | 1.00 (0.88–1.14) | 387 | 1.00 (ref) | 377 | 0.98 (0.85–1.14) | 311 | 0.89 (0.76–1.05) |
| Women age 50 years or above | 158 | 0.95 (0.75–1.21) | 121 | 1.00 (ref) | 128 | 0.88 (0.69–1.14) | 174 | 1.01 (0.78–1.30) |
| Men | 1 026 | 0.99 (0.90–1.10) | 651 | 1.00 (ref) | 614 | 0.93 (0.84–1.04) | 613 | 0.96 (0.85–1.09) |
| Osteoporosis related fractures | ||||||||
| Both sexes | 576 | 1.05 (0.92–1.20) | 358 | 1.00 (ref) | 372 | 1.00 (0.86–1.15) | 370 | 0.98 (0.84–1.15) |
| Women | 290 | 1.08 (0.90–1.31) | 175 | 1.00 (ref) | 187 | 1.04 (0.84–1.28) | 172 | 0.98 (0.78–1.23) |
| Women age 50 years or above | 100 | 1.04 (0.76–1.41) | 70 | 1.00 (ref) | 79 | 0.94 (0.68–1.31) | 108 | 1.06 (0.76–1.47) |
| Men | 286 | 1.02 (0.84–1.23) | 183 | 1.00 (ref) | 185 | 0.96 (0.78–1.18) | 198 | 0.98 (0.79–1.23) |
|
| ||||||||
| 5-year exposure window | 1–9 | 10–19 | 20–39 | ≥40 | ||||
| All fractures | Events; incidence rate ratios (95% confidence interval) | |||||||
| Both sexes | 4 287 | 1.05 (0.99–1.12) | 1 419 | 1.00 (ref) | 1 232 | 1.05 (0.97–1.13) | 787 | 0.97 (0.88–1.06) |
| Women | 1 706 | 1.09 (0.99–1.21) | 538 | 1.00 (ref) | 467 | 1.08 (0.95–1.23) | 272 | 0.97 (0.83–1.13) |
| Women age 50 years or above | 517 | 1.15 (0.97–1.36) | 190 | 1.00 (ref) | 193 | 1.00 (0.81–1.22) | 179 | 1.10 (0.88–1.37) |
| Men | 2 581 | 1.03 (0.95–1.11) | 881 | 1.00 (ref) | 765 | 1.03 (0.93–1.13) | 515 | 0.97 (0.86–1.08) |
| Osteoporosis related fractures | ||||||||
| Both sexes | 1 542 | 1.07 (0.97–1.19) | 519 | 1.00 (ref) | 485 | 1.08 (0.96–1.23) | 341 | 1.05 (0.91–1.22) |
| Women | 808 | 1.05 (0.92–1.21) | 276 | 1.00 (ref) | 243 | 1.04 (0.87–1.24) | 162 | 1.01 (0.82–1.24) |
| Women age 50 years or above | 321 | 1.09 (0.88–1.34) | 124 | 1.00 (ref) | 123 | 0.98 (0.76–1.26) | 116 | 1.11 (0.85–1.45) |
| Men | 734 | 1.10 (0.95–1.28) | 243 | 1.00 (ref) | 242 | 1.13 (0.94–1.35) | 179 | 1.10 (0.89–1.34) |
|
| ||||||||
| 10-year exposure window | 1–19 | 20–39 | 40–79 | ≥80 | ||||
| All fractures | Events; incidence rate ratios (95% confidence interval) | |||||||
| Both sexes | 8 809 | 0.99 (0.94–1.04) | 2 021 | 1.00 (ref) | 1 321 | 0.94 (0.88–1.01) | 654 | 0.95 (0.87–1.04) |
| Women | 3 691 | 0.97 (0.90–1.05) | 829 | 1.00 (ref) | 508 | 0.92 (0.82–1.03) | 221 | 0.92 (0.79–1.08) |
| Women age 50 years or above | 1 280 | 1.04 (0.92–1.16) | 368 | 1.00 (ref) | 291 | 0.98 (0.84–1.14) | 168 | 1.05 (0.87–1.27) |
| Men | 5 118 | 1.01 (0.94–1.07) | 1 192 | 1.00 (ref) | 813 | 0.96 (0.88–1.05) | 433 | 0.96 (0.86–1.08) |
| Osteoporosis related fractures | ||||||||
| Both sexes | 3 378 | 1.04 (0.96–1.12) | 779 | 1.00 (ref) | 579 | 1.04 (0.93–1.16) | 300 | 1.07 (0.94–1.23) |
| Women | 1 855 | 1.02 (0.92–1.14) | 425 | 1.00 (ref) | 307 | 1.03 (0.89–1.20) | 133 | 0.99 (0.81–1.21) |
| Women age 50 years or above | 819 | 1.04 (0.90–1.21) | 233 | 1.00 (ref) | 200 | 1.07 (0.88–1.29) | 111 | 1.12 (0.88–1.41) |
| Men | 1 523 | 1.06 (0.94–1.19) | 354 | 1.00 (ref) | 272 | 1.04 (0.89–1.22) | 167 | 1.16 (0.96–1.41) |