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Geometry for Monte Carlo simulations (not to scale). Background activity distributions (A) and tumor remnant activity distributions (B) were independently simulated. Background (A) and tumor remnant simulations (B) can be scaled and summed to effectively create a tumor remnant in warm background condition (C) with desired tumor remnant:background contrast levels (10:1, 5:1, 3:1, and 2:1 are investigated in this study).
