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. 2018 Jan 4;13(1):e0189396. doi: 10.1371/journal.pone.0189396

Fig 1. Upregulation of LT and non-canonical NF-κB pathway target transcripts in human renal allograft biopsies with AR and IFTA.

Fig 1

LTβ, TNFRs1 and 2, LIGHT and HVEM mRNA expression in human renal biopsies with AR (n = 8; A) or chronic allograft nephropathy (n = 21; B) was significantly increased when compared to controls, which were obtained from nephrectomy specimens after explantation (n = 12). Also, CXCL12, CXCL13, CCL 19 and BAFF showed significant upregulation in AR (C) and IFTA (D). Displayed are fold changes compared to controls (nonaffected renal cortex from renal cancer nephrectomy samples). All fold changes shown were statistically significant compared to controls. (* q-value < 0.05, ** q < 0.01, *** q < 0.001).