Table 2. In-vitro antioxidant activity of drugs showing good anti-glycation activity.
Drug | DPPH Radical scavenging activity | Fe+2 Chelation activity | ||
---|---|---|---|---|
% Inhibition | IC50 ± SEM1 (μM) | % Inhibition | IC50 ± SEM1 (μM) | |
Nimesulide (3) | -17.13 | NA2 | -7.4 | NA2 |
Phloroglucinol dihydrate (11) | -2.5 | NA2 | -2.2 | NA2 |
Gallic acid3 | 93.11 | 23.34 ± 0.43 | ||
EDTA‡ | - | - | 99.99 | 131.00 ± 0.01 |
1IC50 value is presented in μM and as mean ± standard error of mean;
2NA: Not active;
3, ‡Standard inhibitors for antioxidant studies