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. 2018 Jan 4;13(1):e0190291. doi: 10.1371/journal.pone.0190291

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© 2018 Biolo et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — The experimental procedure started at 2 PM, the day of surgery, and continued for the next 48-h, inclusive of the 24-h of IIT and the 24-h of control CIT, administered according to randomized, cross-over protocols. Patients (n = 5) assigned to protocol 1 started with IIT, followed by CIT, while patients (n = 5) assigned to protocol 2 started with CIT followed by IIT. Throughout the 2-day study, glycaemia was determined every 2 hours (▲). The stable isotope infusion to determine erythrocyte glutathione kinetics and oxidative stress, was performed during the last 7 h of insulin treatment, either IIT or CIT (i.e. from 7 AM to 2 PM). Shortly before starting the infusion ( $◆$ ) a blood sample was taken to assess background isotope enrichments and hematochemical and oxidative stress indices. Blood samples were taken at time 3,4,5,6,7 hour ( $▲$ ) to assess the glutathione kinetics.